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In patints with p-xisting liv disas, piodic liv unction tsts a commndd duing th aly stags thapy (s WANINGS ).

A pots indicat that cyclospoin lvls may b incasd duing concomitant tatmnt with ZYLOPIM (allopuinol) . Monitoing cyclospoin lvls and possibl adjustmnt cyclo-spoin dosag should b considd whn ths dugs a co-administd.

This mdicin is usd ttat pvnt mdical poblms that may occu i tomuch uic acid is psnt in th body.

Dnot tak a doubl dos tmak up th dos that you missd. This may incas th chanc you gtting an unwantd sid ct.

Th pots that th concomitant us ZYLOPIM (allopuinol) and thi-azid diutics may contibut tth nhancmnt allopui-nol toxicity in som patints hav bn viwd in an attmpt tstablish a caus-and-ct lationship and a mchanism causation. viw ths cas pots indicats that th patints w mainly civing thiazid diutics hyptnsion and that tsts tul out dcasd nal unction sconday thyptnsiv nphopathy w not otn pomd. In thos patints in whom nal insuicincy was documntd, howv, th commndation tlow th dos ZYLOPIM (allopuinol) was not ollowd. Although a causal mchanism and a caus-and-ct lationship hav not bn stablishd, cunt vidnc suggsts that nal unction should b monitod in patints on thi-azid diutics and ZYLOPIM (allopuinol) vn in th absnc nal ailu, and dosag lvls should b vn mconsvativly adjustd in thos patints on such combind thapy i diminishd nal unction is dtctd.

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